DNA Nanobots Can Fool the Immune System by Disguising Themselves as Viruses



April 23, 2014

Source: Motherboard




Sometimes to help the body, you have to fool the body, which is why researchers from Harvard's Wyss Institute of Biologically Inspired Engineering modeled their latest DNA nanodevice after those great immune-system evaders, viruses.
The whole project, outlined in a new paper published at ACS Nano, is pretty bizarre and cool—back in February 2012, researchers at Wyss announced that they had developed a robotic device fashioned out of DNA. They described how one day the tiny devices could be used for targeting specific, undesirable cells within the body.
The DNAbots were shaped like an open barrel whose two halves are closed by a hinge. When the barrel rolls across, say, a leukemia or lymphoma cell, the special DNA latches could recognize the cell-surface proteins, and the two halves of the barrel could swing open to deliver the DNAbot's payload, which could include molecules with encoded instructions that would interact with specific cell surface signaling receptors, all to give the cells the order to self-destruct. That's the idea, anyway.

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